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James Calloway

James Calloway

MS, Neuroscience
Johns Hopkins University · 8 years experience
Brain Health Sleep Science Mental Health Psychopharmacology

James holds a master's in neuroscience from Johns Hopkins and previously worked in clinical research at a precision psychiatry startup. He covers brain health, sleep science, and mental performance for SelfHacking.

20
Articles
110
Total reading minutes
Articles by James Calloway
The Recovery Industry Is Lying to You About Ice Baths -- What the Research Actually Found
Fitness

The Recovery Industry Is Lying to You About Ice Baths -- What the Research Actually Found

Cold water immersion is everywhere in fitness culture. The feeling of recovery it produces is...

3 min · Jun 20, 2026

Chronic Stress Is Tanking Your Thyroid — And Your TSH Looks Fine
Hormones

Chronic Stress Is Tanking Your Thyroid — And Your TSH Looks Fine

40% of patients with hypothyroid symptoms have normal TSH. Cortisol suppresses TRH, blocks...

2 min · Jun 17, 2026

Why Resting Heart Rate Predicts Your 10-Year Death Risk Better Than Cholesterol
Heart

Why Resting Heart Rate Predicts Your 10-Year Death Risk Better Than Cholesterol

Each 10-beat-per-minute increase in resting heart rate raises all-cause mortality risk by 9%....

4 min · Jun 14, 2026

CBT, Somatic Therapy, and IFS: Which Therapy Modality Actually Works for You?
Mental Health

CBT, Somatic Therapy, and IFS: Which Therapy Modality Actually Works for You?

CBT, somatic therapy, and IFS target different parts of the human system. Here's what the...

12 min · Jun 11, 2026

You Can't Think Your Way Out of a Triggered State — Here's What Actually Works
Mental Health

You Can't Think Your Way Out of a Triggered State — Here's What Actually Works

Most people think emotional regulation means suppression — research shows that's the worst...

14 min · Jun 08, 2026

The Neurobiology of Depression — and Why Standard Treatments Work for Some but Not Others
Mental Health

The Neurobiology of Depression — and Why Standard Treatments Work for Some but Not Others

A complete, honest breakdown of how depression works in the brain, what the evidence shows about...

11 min · Jun 05, 2026

Selank: The Russian Anxiolytic Peptide That Nobody Is Talking About
Supplements

Selank: The Russian Anxiolytic Peptide That Nobody Is Talking About

Selank is a synthetic peptide developed in Russia with anxiolytic and nootropic effects. Unlike...

4 min · Jun 04, 2026

EGCG: The Active Compound in Green Tea That Actually Does Something
Supplements

EGCG: The Active Compound in Green Tea That Actually Does Something

EGCG is the catechin behind green tea's longevity reputation. Here's what the evidence actually...

10 min · Jun 04, 2026

Apigenin: The Chamomile Compound That Protects NAD+, Promotes Sleep, and Supports Testosterone
Sleep

Apigenin: The Chamomile Compound That Protects NAD+, Promotes Sleep, and Supports Testosterone

Apigenin is better known as a component of chamomile tea. But at supplemental doses it also...

9 min · Jun 03, 2026

CoQ10 and Ubiquinol: The Form, the Dose, and Who Actually Needs It
Heart

CoQ10 and Ubiquinol: The Form, the Dose, and Who Actually Needs It

Most people taking CoQ10 are taking the wrong form. Here's the evidence on ubiquinone vs....

11 min · Jun 03, 2026

Ashwagandha: The Deep-Dive into the Most Evidence-Backed Adaptogen
Nutrition

Ashwagandha: The Deep-Dive into the Most Evidence-Backed Adaptogen

Ashwagandha has one of the strongest evidence bases of any supplement. A full breakdown of the...

9 min · Jun 03, 2026

NAD+ and NMN: The Longevity Supplement, Examined
Longevity

NAD+ and NMN: The Longevity Supplement, Examined

NMN is sold as an anti-aging breakthrough. The human evidence is early and modest. Here is what...

1 min · May 25, 2026

Yoga and the Body: Benefits Backed by Research
Fitness

Yoga and the Body: Benefits Backed by Research

Beyond flexibility, yoga has solid evidence for back pain and stress. Here is what the science...

1 min · May 25, 2026

Nootropics 101: A Beginner's Guide to Evidence-Based Cognitive Enhancers
Brain

Nootropics 101: A Beginner's Guide to Evidence-Based Cognitive Enhancers

A no-hype guide to the cognitive enhancers that actually have human evidence behind them, from...

3 min · May 25, 2026

Omega-3s and Fish Oil: Sorting the Evidence from the Hype
Heart

Omega-3s and Fish Oil: Sorting the Evidence from the Hype

Omega-3s (EPA and DHA) have real cardiovascular evidence and a weaker cognitive story. Here is...

1 min · May 25, 2026

Heart Rate Variability: Training by Your Nervous System
Sleep

Heart Rate Variability: Training by Your Nervous System

Heart rate variability promises a window into your recovery and readiness—but it's noisier, more...

3 min · May 25, 2026

Senolytics: Clearing Out the Zombie Cells
Supplements

Senolytics: Clearing Out the Zombie Cells

Senescent cells accumulate with age and poison their neighbors — and a new class of drugs aims...

3 min · May 19, 2026

Zinc and the Immune System, Without the Hype
Supplements

Zinc and the Immune System, Without the Hype

Zinc is genuinely essential for immune function and may shorten a cold by a day or so — but the...

3 min · May 13, 2026

Melatonin: You're Probably Dosing It Wrong
Sleep

Melatonin: You're Probably Dosing It Wrong

Most people take far more melatonin than they need and at the wrong time — it's a timing signal,...

3 min · May 07, 2026

L-Theanine and Caffeine: The Calm-Focus Stack
Brain

L-Theanine and Caffeine: The Calm-Focus Stack

Pairing an amino acid from green tea with your morning coffee is one of the few nootropic stacks...

3 min · May 01, 2026